On Chrome on macOS the default ctrl+n, meta+n will just open a new browser window.
If you replace it with say ctrl+m, meta+m, it will work only if you don't have a form input focused: otherwise it will minimize the window.
The default ctrl+s, meta+s for saving the form, for example on a /node/add/article, will only work if you are not on any form input, otherwise the saving of the web page by the browser will be triggered, which defeates the purpose of this, since you will always save after having inputted something, and the ESC keyboard won't help to unfocus it!
Active
1.1
Code
If you look at keysave module, cmd+s works out of the box even when on an input element of the form, so there should be some way of increasing the priority..
Changed the way that the stopCallback function is attached to the Mousetrap object.