Does the JPEG quality setting under Image toolkit matter?

I've setup reSmush.it pipeline to optimize all of my image styles, then I realized that under Media -> Image Toolkit there is a setting for JPEG quality and that it is currently set to 75%. Will this result in additional compression of my images before or after they are handled by the reSmush.it pipeline? Wondering if I should set this to 100% or leave it as-is for images that are not being handled by the reSmush.it pipeline.