I suspect this is possibly due to file previews, although I haven't dug further into this. I just wanted to report it in case it was unknown.
As part of testing file uploads with limits deactivated, I made a quick random 3GB file from /dev/urandom and since the default upload UI restricted file extensions, I named it random_file.txt
After upload, Drupal was completely unresponsive, even after restarting apache, php-fpm and mariadb until I erased the file from the private files folder. I suspect something was trying to index it - either drupal or this module.
On naming a new test file random_file.gz the issue went away.
I'm guessing something, somewhere, was attempting to read in the entire file for purposes of indexing or preview so figured I should write it up it in case anyone else runs into anything odd with more normal large files.
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So, I feel like I need to retest this scenario with standard drupal media upload, since I don't see any hint of file reads in the media folder code that could explain this.
This could be a bug in drupal itself, even though I also don't see anything odd in the standard core search plugin.