I've encountered an issue where my Views page is failing to load due to entity_reference_exposed_filters' routine for acquiring node titles. At the bottom of \Drupal\entity_reference_exposed_filters\Plugin\views\filter\EREFNodeTitles::generateOptions there is a foreach loop that loads each entity to get its title. If you have a result set that is very large this quickly brings the down. Hopefully there's a more efficient (single query) way of acquiring the node titles.
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1.0
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We were seeing tens of thousands of SQL queries due to this code loading all fields of all entities just to get their labels for the select list. The attached patch uses a custom query to select only the entity ID and label. It resulted in a huge performance improvement for us.